Publications

2021

Crompton, L. A., McComish, S. F., Stathakos, P., Cordero Llana, O., Lane, J. D., Caldwell, M. A. (2021) Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells. JoVE https://www.jove.com/t/62095/efficient-scalable-generation-human-ventral-midbrain-astrocytes-from

2020

Jiménez-Moreno, N, Lane JD (2020) Autophagy and redox homeostasis: a crucial balancing act. Oxidative Medicine and Cellular Longevity https://doi.org/10.1155/2020/8865611

Moss, JJ, Hammond, CL, Lane JD (2020) Zebrafish as a model to study autophagy and its role in skeletal development and disease. Histochemistry and Cell Biology 154, 549–564

Antón, Z, Mullally, G, Ford, H, van der Kamp, MW, Szczelkun, MD, Lane JD (2020) Variability in mitochondrial import, mitochondrial health and mtDNA copy number using Type II and Type V CRISPR effectors. Journal of Cell Science

Antón, Z, Betin, VMA, Simonetti, B, Traer, C, Attar, N, Cullen, P, Lane JD (2020) A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly. Journal of Cell Science

Stathakos, PJiménez-Moreno, NCrompton, LNistor, PBadger, JBarbuti, PKerrigan, TRandall, A, Caldwell, M, Lane, JD (2020) A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy https://doi.org/10.1080/15548627.2020.1739441

2019

Baines, K, Lane, JD (2019) The ATG5 Interactome Links Clathrin Vesicular Trafficking With The ATG8 Lipidation Machinery For Autophagosome Assembly. bioRxiv https://www.biorxiv.org/content/10.1101/769059v1

Jiménez-Moreno, N, Stathakos, P, Antón, Z, Shoemark, DK, Sessions, RB, Witzgall, R, Caldwell, M, Lane, JD (2019) LIR-dependent LMX1A/LMX1B autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. bioRxiv https://doi.org/10.1101/636712

Anderson, MW, Moss, JJ, Szalai, R & Lane JD (2019) Mathematical modelling highlights the complex role of AKT in TRAIL-induced apoptosis of HCT116 colorectal carcinoma cells. iScience 12:182-193

Stathakos, P, Jimenez-Moreno, N, Crompton, L, Nistor, P, Caldwell, MA & Lane, JD (2019) Imaging autophagy in hiPSC-derived midbrain dopaminergic neuronal cultures for Parkinson’s disease research. Methods Mol. Biol. 1880: 257-280

Mansell, E, Zareian, N, Malouf, C, Kapeni, C, Brown, N, Badie, C, Baird, D, Lane, JD, Ottersbach, K, Blair, A & Case, CP (2019) DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation. Scientific Reports 9: 4370

2018

Albertini, MC, Proikas-Cezanne, T, Engedal, N, Zerovnik, E & Lane, JD (2018) Transautophagy: research and translation of autophagy knowledge – Editorial. Oxidative Medicine & Cellular Longevity 7504165

Hawkins SJ, Crompton LA, Sood A, Saunders M, Boyle N, Buckley A, Minogue AM, McComish S, Jiménez-Moreno N, Cordero-Llana O, Stathakos P, Kelly S, Lane JD, Case CP & Caldwell MA (2018) Nanoparticle induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes. Nature Nanotechnology 13: 427–433

2017

Lane JD, Korolchuk VI & Murray JT (2017) Signalling mechanisms in autophagy: an introduction to the issue – Editorial. Essays in Biochemistry 61: 1-3

Signalling mechanisms in autophagy (2017). Portland Press. Eds. Lane JD, Korolchuk VI & Murray, JT. Essays in Biochemistry 61(6)

Lane JD & Agostinis P (Eds) (2017) Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy – Editorial. Front. Oncol. doi: 10.3389/fonc.2017.00302

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy (Frontiers – eBook) Lane JD & Agostinis P (Eds) (2017) Frontiers in Oncology

Jiménez-Moreno N, Stathakos P, Caldwell M, Lane JD (2017) Induced pluripotent stem cell neuronal models for the study of autophagy pathways in human neurodegenerative disease. Cells 6(3), 24; doi:10.3390/cells6030024

2016

Casas C, Codogno P, Pinti M, Batoko H, Moran M, Proikas-Cezanne T, Reggiori F, Sirko A, Soengas MS, Velasco G, Lafont F, Lane J, Faure M, Cossarizza A. (2016) TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge. Autophagy 12: 614-617

Klionsky DJ et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd Edition). Autophagy 12: 1-222

2015

MacVicar TDB, Mannack VJC*, Lees RM & Lane JD (2015) Targeted siRNA screens identify ER-to-mitochondrial calcium exchange in autophagy and mitophagy responses in RPE1 cells. International Journal of Molecular Sciences 16: 13356-13380

Liang J-R, Martinez A, Lane JD, Mayor U, Clague MJ, Urbé A (2015) USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death. EMBO reports 16: 618-627

Morgan R, Molnar E, Jones R, Collard T, Lane JD, Greenhough A, Paraskeva C & Williams AC (2015) Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells. British Journal of Cancer 112: 714-719

Mannack LVJC & Lane JD (2015): The autophagosome: current understanding of formation and maturation. Research and Reports in Biochemistry 5: 39-58

2014

Curtis DJ, Sood A, Phillips TJ, Leinster VH, Nishiguchi A, Coyle C, Lacharme-Lora L, Beaumont O, Kemp H, Goodall R, Cornes L, Giugliano M, Barone RA, Matsusaki M, Akashi M, Tanaka HY, Kano M, McGarvey J, Halemani ND, Simon K, Keehan R, Ind W, Masters T, Grant S, Athwal S, Collett G, Tannetta D, Sargent IL, Scull-Brown E, Liu X, Aquilina K, Cohen N, Lane JD, Thoresen M, Hanley J, Randall A, Case CP (2014): Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions. Exp Neurol. 261: 386-395

MacVicar TDB, Lane JD (2014): Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation. Journal of Cell Science 15: 2313-2315

2013

Autophagy: Molecules and Mechanisms (Essays in Biochemistry) (2013). Portland Press ISSN Print: 0071-1365; ISSN Electronic: 1744-1358. Ed. Lane JD.

Petherick KJ, Williams AC, Lane JD, Ordóñez-Morán P, Huelsken J, Collard TJ, Smartt HJ, Batson J, Malik K, Paraskeva C, Greenhough A (2013): Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. EMBO J. 32: 1903-1916.

Raghunathan VK, Devy M, Hawkins S, Hails L, Davis, S Mann S, Chang I, Ingam, E, Malhas A, Vaux DJ, Lane JD & Case PC (2013): Influence of particle size and reactive oxygen species on colbalt chrome nanoparticle-mediated genotoxicity. Biomaterials 34(14):3559-70.

Weir HJM, Lane JD*, Balthasar N (2013): SIRT3: a central regulator of mitochondrial adaptation in health and disease. Genes & Cancer doi:10.1177/1947601913476949. (* Corresponding author.)

Betin VMS, Singleton B, Parsons SF, Anstee DJ*, Lane JD* (2013): Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogues during autophagosome maturation. Autophagy 9:881-893) (* Joint corresponding authors.)

2012

Weir HJM, Murray TK, Kehoe PG, Love S, O’Neill MJ, Lane JD*, Balthasar N* (2012): CNS Sirt3 expression is altered by reactive oxygen species and in Alzheimer’s disease. PLOS one 7(11):e48225 (* Joint corresponding authors.)

Klionsky, DJ & 1268 others (2012): Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544.

Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VMS, Trakarnsanga K, Massey EJ, Parsons SF, Anstee DJ, Lane JD (2012): The ins & outs of reticulocyte maturation: Autophagy and the endosome/exosome pathway. Autophagy 8: 1150-51.

Griffiths RE, Kupzig S, Cogan N, Mankelow TJ, Betin VMS, Trakarnsanga K, Massey EJ, Lane JD*, Parsons SF, Anstee DJ* (2012): Maturing reticulocytes internalise plasma membrane in Glycophorin A- containing vesicles which fuse with autophagosomes prior to exocytosis. Blood 119: 6296-6306. (* Joint corresponding authors.)

Betin VMS, MacVicar TBD, Parsons SF, Anstee DJ, Lane JD (2012): A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress. Autophagy 8:664-676.

2010

Cheng JPX, Betin VMS, Weir H, Shelmani GMA, Moss DK & Lane JD (2010): Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis. Cell Death & Disease 1, e82; doi:10.1038/cddis.2010.59.

Cheng JPX & Lane JD (2010): Organelle dynamics and membrane trafficking in apoptosis and autophagy. Histology & Histopathology 25: 1457-1472.

Patsos HA, Greenhough A, Hicks DJ, Al Kharusi M, Collard TJ, Lane JD, Paraskeva C, Williams AC. (2010): The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. Int J Oncol. 37:187-93.

Klionsky, DJ, Lane JD (2010): Alternative macroautophagy. Autophagy 7: 6

2009

Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant S, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R & Case CP (2009): Nanoparticles can cause DNA damage across a cellular barrier. Nature Nanotechnology 4: 876-883

Betin, VMS & Lane JD (2009): Atg4D at the interface between autophagy and apoptosis. Autophagy 5: 1057-1059.

Betin, VMS & Lane JD (2009): Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci. 122: 2554-2566.

Moss DK, Wilde A, Lane JD (2009): Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. J. Cell Sci. 122: 644-655

2008

Betin VMS & Lane JD (2008) The cytoskeleton and the control of organelle dynamics in the apoptotic execution phase. In the Eukaryotic Cell Cycle, SEB Symposium Series 59: 267-289 (Eds Bryant & Francis).

2006

Moss, DK & Lane, JD (2006) Microtubules: forgotten players in the apoptotic execution phase. Trends in Cell Biology 16: 330-338

Moss DK, Betin VMS, Malesinski, SD & Lane JD (2006): A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation. J. Cell Sci. 119: 2362-2374

(this article is listed by the Faculty of 1000 – see link).

2005

Patsos HA, Hicks DJ, Dobson RRH, Greenhough A, Woodman N, Lane JD, Williams AC & Paraskeva C (2005) The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. Gut 54: 1741-1750.

Lane JD*, Woodman PG, Allan VJ (2005) Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells. J. Cell Sci. 118: 4059-4071. (* Corresponding author.)

Lane JD & Stebbings H (2005) Transmitted light imaging. Cell Imaging – Methods Express, Ed. Stephens D (Scion Publishing Ltd).

2004

Lowe M, Lane JD, Woodman PG, Allan VJ (2004) Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis. J. Cell Sci. 117: 1139-1150.

2002

Lane JD, Lucocq J, Pryde J, Woodman PG, Allan VJ, Lowe M (2002) Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis. J. Cell Biol. 156: 495-509.

(this article was featured as front cover and in the JCB editorial section – see link – and was Editor’s choice in Science – see link. It was also listed in the Faculty of 1000 – see link)

2001

Lane JD, Vergnolle MAS, Woodman PG & Allan VJ (2001) Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150Glued stops dynein-dependent membrane motility. J. Cell Biol. 153: 1412-1426.

(this article was Editor’s choice in Science – see link)

1990’s

Lane JD & Allan VJ (1999) Microtubule-based endoplasmic reticulum motility in Xenopus laevis: activation of membrane-associated kinesin during development. Mol. Biol. Cell 10: 1909-1922.

Lane JD & Allan VJ (1998) Microtubule-based membrane movement. BBA Reviews on Biomembranes 1376: 27-55.

Lane JD & Stebbings H (1998) Phosphorylation of microtubule-associated proteins from the ovaries of hemipteran insects by MPF and MAP kinase. Arch. Insect Biochem. Physiol. 39: 81-90.

Lane JD & Stebbings H (1995) Reorganisation of microtubule arrays in the telotrophic ovaries of hemipteran insects: Correlation with meiotic reinitiation. Roux’s Arch. Dev. Biol. 205: 150-159.

Stebbings H, Lane JD & Talbot NJ (1995) mRNA translocation and microtubules: insect ovarian models. Trends Cell Biol. 5: 361-365.

(this article was featured as front cover)

Lane JD & Stebbings H (1994) Independent regulation of microtubule spacing and microtubule stability following redundancy of nutritive tubes in telotrophic ovaries in Hemiptera (Insecta). Int. J. Insect Morphol. Embryol. 23: 297-309.