People

Professor Jon Lane

Jon joined the School of Biochemistry at Bristol in 2003, initially on a Wellcome Trust Career Development Fellowship to study membrane trafficking in apoptosis. He soon gained an interest in the molecular regulation of autophagy, and the Lane lab now focuses on the roles of autophagy in mammalian cell stress responses in health and disease. jon.lane@bristol.ac.uk

Current Lane Lab Members:

Dr Madhu Kollareddy

Madhu is working on a BBSRC-funded project to explore Autophagy-transcriptional cross-talk in differentiation and cell health.

 

Joanna Moss

IMG_0198Joanna is on the Wellcome Trust Dynamic Molecular Cell Biology PhD programme. She is studying the role of autophagy in development and osteoarthritis using cell-lines and zebrafish in a collaboration with Chrissy Hammond. joanna.moss@bristol.ac.uk

 

 

 

Avi Nair

Avi is a Bristol Biochemistry graduate who has joined the lab to study the role of autophagy during astrocyte/neuronal conversion and Parkinson’s-related neuroinflammation. an17643@bristol.ac.uk

 

 

Tom Trainer

Tom has joined the lab as an MRes student. He will be studying autophagy and Parkinson’s neuroinflammatory signalling in astrocytes. Tom studied for a BSc in Reading where he used C. elegans to identify novel lysosomal Parkinson’s genes. t.trainer@bristol.ac.uk

 

 

Yiming Zhang

Yiming is a PhD student co-supervised with Dr Denize Atan and Dr Liang-Fong Wong. Yiming is studying a transcriptional repressor important for retinal development.

Affiliated with the Lane Lab:

James Lorriman

James is a Wellcome Trust PhD student on the Dynamic Molecular Cell Biology Programme. James is doing his PhD on mitochondrial quality control with Ian Collinson, but with close links with the Lane lab.  jl16537@Bristol.ac.uk

Previous Lane Lab Members :

Dr Lucy Crompton

Lucy

Lucy is a Parkinson’s UK funded Postdoc studying neuroinflammatory signaling between glia and dopaminergic neurons in Parkinson’s. Lucy uses human iPSC neural co-culture models. Lucy.Crompton@bristol.ac.uk

 

 

Chris Sharrock – Chris was a rotation student on the Wellcome Trust Dynamic Molecular Cell Biology PhD Programme. He studied astrocyte cell death and inflammatory signalling in Parkinson’s. di20975@bristol.ac.uk

 

 

 

 

Abby Weston – Abby was an MSc Research student studying ESCRT complex proteins during autophagosomal closure. She has now moved on to study the biochemistry of thirst at King’s. gf19552@bristol.ac.uk

 

 

 

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Dr Natalia Jimenez Moreno – Natalia was a PhD student on the Wellcome Trust Dynamic Cell Biology PhD Programme. She studied autophagy transcriptional control in Parkinson’s using iPSC-derived human dopamine neurones. Natalia has joined the Wilkinson lab in Edinburgh to study selective autophagy and ER quality control. nj15108@bristol.ac.uk

 

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Dr Phil Regan – Phil was an Alzheimer’s Society funded Postdoc working on a short project with the Lane Lab, Maeve Caldwell, Seth Love and Andy Randall, looking at astrocyte behaviour in APOE background using iPSC-derived cells. plr25@bath.ac.uk

 

 

 

Dr Beatriz Castejón – Screenshot 2019-05-20 at 15.13.23Bea was a PhD student working in Mario Cordero’s lab in Seville on the role of autophagy in Tay-Sachs disease. She joined us for 6 months courtesy of the Company of Biologists and TransAutophagy travel Fellowships to make iPSCs for neuronal work.   beacastej92@outlook.es

ZuriDr Zuri Antón– Zuri worked on the MitoCRISPR project alongside Holly Ford in the Szczelkun lab. She is now a postdoc in the Dodding lab za16870@bristol.ac.uk

 

 

 

Fionnuala McMorrow – Finny was a Biochemistry MSci student working on LC3IMG_1242 mutations and autophagosome assembly.

 

 

 

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Tiah Oates – Tiah is a Wellcome Trust 4-yr PhD student who rotated in the Lane lab in the Autumn of 2018. Tiah studied lipid droplet formation and the autophagy pathway in iPSC-derived human midbrain astrocytes. She is doing her PhD with Ash Toye. yr18439@bristol.ac.uk

 

 

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Dr Grace Mullally – Grace was BBSRC SWDTP PhD project with Mark Szczelkun. She studied genome editing in mitochondria in relation to human mitochondrial diseases. grace.mullally@bristol.ac.uk

 

 

 

Kiren

Dr Kiren Baines – Kiren was a Wellcome Trust Dynamic Cell Biology PhD student. She used quantitative proteomics to characterise the molecular components of the early autophagosome assembly site. kb13487@mybristol.ac.uk

 

 

Dr Petros Stathakos – Petros was an MRC-funded PhD student, jointly supervised by Maeve IMG_0288Caldwell in Trinity College, Dublin. Petros used iPSC derived patient neurones to study mitochondrial quality control systems in Parkinson’s disease.

 

 

Dr Matt Anderson – Matt did his PhD on the Complexity Science PhD programme, IMG_0834working with Robert Szalai in Engineering/Maths. He is now a Research Fellow at the Living Systems Institute at Exeter University. M.W.Anderson@exeter.ac.uk

 

 

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Dr Chris Parker – Chris joined the lab on the Wellcome Trust 4-Year Dynamic Cell Biology PhD programme. He developed tools to test how autophagy contributes to axon growth dynamics and targeting. cp16426@bristol.ac.uk

 

Dr Els Mansell – Els was a PhD student on a joint Children with Cancer project with Patrick Case and Allison Blair. She started her project in October 2012 and studied how the human placenta contributes to damage signalling in models of childhood leukaemia. elsmansell@gmail.com

Dr Richard Seager – Richard worked in the lab for a ~3 month rotation on the Wellcome Trust Dynamic Cell Biology programme. He explored how mediators of mitochondrial dynamics influence mitophagy capability. Richard did his PhD in Jeremy Henley’s lab. rs15570@bristol.ac.uk

IMG_0302Dr Jenni Gurnett  Jenni joined the lab on a Research Masters. She screened for molecular motors regulating autophagosome assembly. Jenni completed her PhD in Leicester.

 

Dr Virginie Betin – Virginie was the first Lane lab member, and worked with Jon for 11 years. Following a short joint project between Jon and Prof. Mark Szczelkun looking at mitochondrial DNA replication and quality control, Virginie is now working as a postdoc with Richard Coward in the Dorothy Hodgkin Building in Bristol. v.m.s.betin@bristol.ac.uk

Dr Lilith Mannack – Lilith joined the lab in October 2010, as astudent on the MRC Quantitative Imaging of Cellular Dynamics PhD Programme. She explored the regulation of mammalian autophagosome assembly using quantitative cell imaging. Lilith is now working as a teacher.

Dr Rob Lees – Rob rotated in the lab during the first year of his Wellcome Trust Dynamic Cell Biology PhD. He studied the influence of SigmaR1 on autophagic flux. Rob’s work included in a study published in the International Journal of Molecular Sciences. Rob carried out his PhD with Mike Ashby.  

Dr Tom MacVicar – Tom was a Wellcome Trust PhD student who worked on Parkin-mediated mitophagy and mitochondrial dynamics control. He went on to work as a Postdoc in Thomas Langer’s lab where he held an EMBO Fellowship, and is now starting his own lab in Glasgow as a CRUK Fellow. 

Catherine Eagle – Catherine joined the lab as a rotation student on the Wellcome Trust Dynamic Cell PhD programme. She investigated how mitochondrial dynamics and mitophagy regulate mitochondrial quality control in models of human mitochondrial disease.

HeatherDr Heather Weir – Heather was a PhD student on a joint project with
Nina Balthasar, to investigate the role of the sirtuin, Sirt3, in mitochondrial stress and neurodegeneration. Heather is currently ‘Postdoc’-ing in Will Mair’s lab in Boston.

 

 

Dr Jessica Campbell – Jess joined the lab on a 12-week roation project on the Wellcome Trust Dynamic Cell PhD Programme. She studied the roles of autophagy and GRASP proteins during non-canonical secretion. Jess did her PhD with Kate Nobes.

JadeDr Jade Cheng – Jade joined the lab in October 2007, as a BBSRC funded PhD student. She explored the relationships between Golgi structure/function and apoptotic susceptibility. Jade has now joined Ben Nichols’ lab as a PostDoc. Jade is now a patent attorney.

 

 

Dr Malgorzata Piechota – Gosia joined the lab for a few months to study autophagy. She is interested in the roles of autophagy in retinopathies. For her PhD she characterised a model of Autosomal Dominant Optic Atrophy in the labs of Dr Marcela Votruba and Prof. Michael Boulton in Cardiff.

Dr Vijay Krishna Raghunathan – Vijay worked on a joint project with Dr Patrick Case looking at the genotoxic/cytotoxic impact of metal nanoparticles derived from surgical implants. Vijay has his own lab at the College of Optometry, Houstonvraghunathan@uh.edu 

Dr Ian McGough – Ian joined the lab for 3 months as a Wellcome Trust PhD rotation student. He investigated the function of Atg4C in epithelial cells. Ian went off to do his PhD with Pete Cullen, and following Postdocs with J-P Vincent, is now setting up his own lab at the Babraham.

Dr David Moss – David worked as a Postdoc in the lab until Autumn 2007 studying the regulation of microtubules in apoptotic cells. He now works at the NIMR, Mill Hill.